A new study has shown what we have known for some time in functional medicine: Chronic inflammation causes brain fog and mental sluggishness — many people with chronic health conditions report these symptoms.

People who live, work, or go to school in moldy buildings complain of pain, fatigue, increased anxiety, depression, and cognitive defects such as memory loss. Researchers say the symptoms are similar to those from bacterial or viral infections, due to the inflammatory cascades mold triggers.

Working with your hands on something physical boosts reward circuits in the brain in ways working abstractly only with your brain doesn’t. This in turn triggers a cascade of neurochemical reactions that improve motivation and self-esteem and relieve depression.